1,3-Dichloropropane
Names
[ CAS No. ]:
142-28-9
[ Name ]:
1,3-Dichloropropane
[Synonym ]:
Propandiyldichlorid
1,3-dichloropropan-2-one O-benzyloxime
MFCD00000999
1,3-dichloro-2-propanone O-benzyloxime
EINECS 205-531-3
1,3-Dichlor-propan
1,3-dichloro-propane
Propane, 1,3-dichloro-
1,3-Dichloropropane
Trimethylene dichloride
1,3-dichlorpropane
Trimethylene Chloride
3-chloropropyl chloride
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
120.4±0.0 °C at 760 mmHg
[ Melting Point ]:
−99 °C(lit.)
[ Molecular Formula ]:
C3H6Cl2
[ Molecular Weight ]:
112.986
[ Flash Point ]:
32.2±0.0 °C
[ Exact Mass ]:
111.984657
[ LogP ]:
2.00
[ Vapour Pressure ]:
18.3±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.422
[ Water Solubility ]:
0.8 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TX9660000
- CHEMICAL NAME :
- Propane, 1,3-dichloro-
- CAS REGISTRY NUMBER :
- 142-28-9
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C3-H6-Cl2
- MOLECULAR WEIGHT :
- 112.99
- WISWESSER LINE NOTATION :
- G3G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3600 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - other changes Blood - hemorrhage
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8400 mg/kg/14D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Metabolism (Intermediary) - other proteins
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 72 gm/kg/90D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 6600 umol/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9,401,1987
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H226-H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
F:Flammable
[ Risk Phrases ]:
R11;R20/22
[ Safety Phrases ]:
S9-S16-S29-S33-S24-S61-S26-S45-S36/37-S7
[ RIDADR ]:
UN 1993 3/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
TX9660000
[ Packaging Group ]:
II
[ Hazard Class ]:
3
[ HS Code ]:
2903199000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2903199000
[ Summary ]:
2903199000 other saturated chlorinated derivatives of acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
Articles
Drug Metab. Dispos. 32(1) , 123-31, (2004)
Cytochrome P450-dependent oxidation and glutathione (GSH)-dependent conjugation are the primary routes of metabolism of haloalkanes. Using rat liver microsomes and cytosol, we investigated the metabol...
1,3-Dichloropropene (technical grade).Rep. Carcinog. 10 , 91-3, (2002)
Biological effect monitoring.
Arch. Toxicol. Suppl. 15 , 268-77, (1992)