Oxetane
Names
[ CAS No. ]:
503-30-0
[ Name ]:
Oxetane
[Synonym ]:
MFCD00005167
Oxacyclobutane
Trimethylene oxide/Oxetane
1,3-Epoxypropane
Trimethylene Oxide
Oxetane
Cyclooxabutane
EINECS 207-964-3
Trimethylene oxide (8CI)
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
49.0±0.0 °C at 760 mmHg
[ Melting Point ]:
-97°C
[ Molecular Formula ]:
C3H6O
[ Molecular Weight ]:
58.079
[ Flash Point ]:
-32.0±15.3 °C
[ Exact Mass ]:
58.041866
[ PSA ]:
9.23000
[ LogP ]:
-0.24
[ Vapour Pressure ]:
317.0±0.0 mmHg at 25°C
[ Index of Refraction ]:
1.412
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RQ6825000
- CHEMICAL NAME :
- Oxetane
- CAS REGISTRY NUMBER :
- 503-30-0
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C3-H6-O
- MOLECULAR WEIGHT :
- 58.09
- WISWESSER LINE NOTATION :
- T4OTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2240 mg/kg/56W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 3333 ug/plate
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11(Suppl 12),1,1988
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H302-H312-H332
[ Precautionary Statements ]:
P210-P280
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)
[ Hazard Codes ]:
F:Highlyflammable;Xn:Harmful;
[ Risk Phrases ]:
R11;R20/21/22
[ Safety Phrases ]:
S9-S16-S26-S29
[ RIDADR ]:
UN 1993 3/PG 2
[ WGK Germany ]:
1
[ RTECS ]:
RQ6825000
[ Packaging Group ]:
II
[ Hazard Class ]:
3
[ HS Code ]:
2932999099
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2932999099
[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Chem. Commun. (Camb.) 49(28) , 2930-2, (2013)
The first synthesis of highly substituted 3-alkyl-oxetan-2-ylidenes from allenoates was developed by using the bicyclic guanidine 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as an exceptionally active n...
A selective intramolecular transacylation of taxoids accompanying with the oxetane ring opening.Chem. Pharm. Bull. 60(3) , 415-8, (2012)
A selective intramolecular transacylation from C-4 to C-5 of taxoids, which occurred simultaneously with the oxetane D-ring opening and was promoted by TiCl4, was presented. The optimal condition was ...
Three-component assembly and divergent ring-expansion cascades of functionalized 2-iminooxetanes.Angew. Chem. Int. Ed. Engl. 49(48) , 9210-4, (2010)