1,3-Propanediol

Names

[ CAS No. ]:
504-63-2

[ Name ]:
1,3-Propanediol

[Synonym ]:
1,3-Dihydroxypropane
Propan-1,3-diol
MFCD00002949
1,3-Propane diol
propylene glycol
I,3-Propandiol
Trimethylene glycol
2-Deoxyglycerol
1,3-Propylene glycol
1,3-Propandeiol
1,3-Propylenediol
1,3-PROPANDIOL
Propane-1,3-diol
1,3-Dihydroxypropane,Bio-PDO,PG
EINECS 207-997-3
PDO
1,3-Propanediol
1,3-prpanediol

Biological Activity

[Description]:

1,3-Propanediol is produced in nature by the fermentation of glycerol in microorganism[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. F. Barbirato, et al. Glycerol fermentation by a new 1,3-propanediol-producing microorganism:Enterobacter agglomerans. Applied Microbiology and Biotechnology volume 43, pages786-793(1995).

Chemical & Physical Properties

[ Density]:
1.052

[ Boiling Point ]:
214.4±0.0 °C at 760 mmHg

[ Melting Point ]:
-32 °C

[ Molecular Formula ]:
C₃H₈O₂

[ Molecular Weight ]:
76.094

[ Flash Point ]:
79.4±0.0 °C

[ Exact Mass ]:
76.052429

[ PSA ]:
40.46000

[ LogP ]:
-1.04

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.434

[ Water Solubility ]:
100 g/L

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TY2010000

CHEMICAL NAME :: 1,3-Propanediol

CAS REGISTRY NUMBER :: 504-63-2

BEILSTEIN REFERENCE NO. :: 0969155

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C3-H8-O2

MOLECULAR WEIGHT :: 76.11

WISWESSER LINE NOTATION :: Q3Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10930 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 2100 mg/kg/10W (Continuous)

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 50,87,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82065 No. of Facilities: 85 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 1040 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82065 No. of Facilities: 652 (estimated) No. of Industries: 14 No. of Occupations: 18 No. of Employees: 12083 (estimated) No. of Female Employees: 126 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
38

[ Safety Phrases ]:
S23-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
TY2010000

[ HS Code ]:
29053980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2905399001

[ Summary ]:
2905399001 propane-1,3-diol。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:5.5%。general tariff:30.0%

Articles

Activation of Tomato Bushy Stunt Virus RNA-Dependent RNA Polymerase by Cellular Heat Shock Protein 70 Is Enhanced by Phospholipids In Vitro.

J. Virol. 89(10) , 5714-23, (2015)

Similar to other positive-strand RNA viruses, tombusviruses are replicated by the membrane-bound viral replicase complex (VRC). The VRC consists of the p92 virus-coded RNA-dependent RNA polymerase (Rd...

Anomalously large isotope effect in the glass transition of water.

Proc. Natl. Acad. Sci. U. S. A. 111(49) , 17402-7, (2014)

We present the discovery of an unusually large isotope effect in the structural relaxation and the glass transition temperature Tg of water. Dielectric relaxation spectroscopy of low-density as well a...

Effect of 1,3-propanediol, organic acids, and ethanol on growth and metabolism of Clostridium butyricum DSP1.

Appl. Microbiol. Biotechnol. 99(7) , 3179-89, (2015)

Knowledge of tolerance of bacteria to toxic stress is important, especially for processes targeted at high final titers of product. Information on environmental limits and stress responses may help du...