Methyl 3-hydroxypropanoate

Names

[ CAS No. ]:
6149-41-3

[ Name ]:
Methyl 3-hydroxypropanoate

[Synonym ]:
Methyl 3-hydroxypropanoate
Propanoic acid, 3-hydroxy-, methyl ester
methyl 3-hydroxypropionate

Biological Activity

[Description]:

Methyl 3-hydroxypropanoate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
180.5±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄H₈O₃

[ Molecular Weight ]:
104.104

[ Flash Point ]:
72.6±12.6 °C

[ Exact Mass ]:
104.047340

[ PSA ]:
46.53000

[ LogP ]:
-0.90

[ Vapour Pressure ]:
0.3±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.414

MSDS

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Safety Information

[ HS Code ]:
2918199090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%