Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2

Modify Date: 2024-01-12 10:17:00

Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 Structure
Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 structure
Common Name Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2
CAS Number 141663-86-7 Molecular Weight 900.07400
Density N/A Boiling Point N/A
Molecular Formula C47H65N9O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2


GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2].

 Names

Name Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2
Synonym More Synonyms

 Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 Biological Activity

Description GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2].
Related Catalog
Target

NK2

In Vitro GR 87389 是一种非肽和肽速激肽拮抗剂,对海马、膀胱和十二指肠的 Ki 值分别为 4.0、5.2 和 14 nM[1]。 GR 87389 (30-300 nM) 拮抗 GA 64349 诱导的人类逼尿肌、前列腺和前列腺尿道平滑肌条收缩[2]。
References

[1]. Saffroy M, et, al. Presence of NK2 binding sites in the rat brain. J Neurochem. 2001 Dec;79(5):985-96.  

[2]. Palea S, et, al. Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate. J Pharmacol Exp Ther. 1996 May;277(2):700-5.  

 Chemical & Physical Properties

Molecular Formula C47H65N9O9
Molecular Weight 900.07400
Exact Mass 899.49100
PSA 254.23000
LogP 5.01350

 Synonyms

boc-ala-ala-d-trp-phe-d-pro-pro-nle-nh2
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