Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2
Names
[ CAS No. ]:
141663-86-7
[ Name ]:
Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2
[Synonym ]:
boc-ala-ala-d-trp-phe-d-pro-pro-nle-nh2
Biological Activity
[Description]:
GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2].
[Related Catalog]:
[Target]
NK2
[In Vitro]
GR 87389 是一种非肽和肽速激肽拮抗剂,对海马、膀胱和十二指肠的 Ki 值分别为 4.0、5.2 和 14 nM[1]。 GR 87389 (30-300 nM) 拮抗 GA 64349 诱导的人类逼尿肌、前列腺和前列腺尿道平滑肌条收缩[2]。
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C47H65N9O9
[ Molecular Weight ]:
900.07400
[ Exact Mass ]:
899.49100
[ PSA ]:
254.23000
[ LogP ]:
5.01350