Verosudil(AR-12286)

Modify Date: 2024-01-08 11:58:54

Verosudil(AR-12286) structure	Common Name	Verosudil(AR-12286)
	CAS Number	1414854-42-4	Molecular Weight	327.401
	Density	1.3±0.1 g/cm3	Boiling Point	625.5±55.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₇N₃O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	332.1±31.5 °C

Use of Verosudil(AR-12286)

Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork[1][2].

Name	verosudil
Synonym	More Synonyms

Description	Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork[1][2].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Research Areas >> Neurological Disease Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK
Target	ROCK1:2 nM (Ki) ROCK2:2 nM (Ki) PKA:69 nM (Ki) MRCKA:28 nM (Ki) CAM2A:5855 nM (Ki) PKC theta:9322 nM (Ki)
References	[1]. Lin CW, Sherman B, Moore LA, et al. Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma. J Ocul Pharmacol Ther. 2018;34(1-2):40‐51. [2]. Kopczynski C, Novack GD, Swearingen D, van Haarlem T. Ocular hypotensive efficacy, safety and systemic absorption of AR-12286 ophthalmic solution in normal volunteers. Br J Ophthalmol. 2013;97(5):567‐572.

Density	1.3±0.1 g/cm3
Boiling Point	625.5±55.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₇N₃O₂S
Molecular Weight	327.401
Flash Point	332.1±31.5 °C
Exact Mass	327.104156
LogP	0.84
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.666

verosudil

UNII:MAF34143WM

2-(Dimethylamino)-N-(1-oxo-1,2-dihydro-6-isoquinolinyl)-2-(3-thienyl)acetamide

3-Thiopheneacetamide, N-(1,2-dihydro-1-oxo-6-isoquinolinyl)-α-(dimethylamino)-

UNII: MAF34143WM

AR-12286

MAF34143WM

DC Chemicals Limited
China
Product Name: Verosudil(AR-12286)
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Verosudil
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Verosudil(AR-12286)

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