u-Conotoxin GIIIB

Modify Date: 2025-08-25 17:40:43

u-Conotoxin GIIIB structure	Common Name	u-Conotoxin GIIIB
	CAS Number	140678-12-2	Molecular Weight	2640.17
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀₁H₁₇₅N₃₉O₃₀S₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of u-Conotoxin GIIIB

μ-Conotoxin GIIIB is a 22-residue polypeptide that can be isolated from the venom of piscivorous cone snail Conus geographus. μ-Conotoxin GIIIB is a NaV1.4 channel inhibitor. μ-Conotoxin GIIIB blocks muscle cell's contraction[1][2][3].

Name	μ-CONOTOXIN GIIIB
Synonym	More Synonyms

Description	μ-Conotoxin GIIIB is a 22-residue polypeptide that can be isolated from the venom of piscivorous cone snail Conus geographus. μ-Conotoxin GIIIB is a NaV1.4 channel inhibitor. μ-Conotoxin GIIIB blocks muscle cell's contraction[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	NaV1.4 Channel[2]
References	[1]. orres NS. Activation of reverse Na+-Ca2+ exchanger by skeletal Na+ channel isoform increases excitation-contraction coupling efficiency in rabbit cardiomyocytes. Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H593-H603. [2]. Garcia N, et al. Involvement of the Voltage-Gated Calcium Channels L- P/Q- and N-Types in Synapse Elimination During Neuromuscular Junction Development. Mol Neurobiol. 2022 Jul;59(7):4044-4064. [3]. Hill JM, et al. Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels. Biochemistry. 1996 Jul 9;35(27):8824-35.

Molecular Formula	C₁₀₁H₁₇₅N₃₉O₃₀S₇
Molecular Weight	2640.17
Exact Mass	2638.14000
PSA	1338.14000

Safety Phrases	22-24/25
RIDADR	UN 3462 6
Packaging Group	III
Hazard Class	6.1(b)

Conotoxin GIIIB

U-conotoxin giiib

ARG-ASP-CYS-CYS-THR-HYP-HYP-ARG-LYS-CYS-LYS-ASP-ARG-GLN-CYS-LYS-HYP-GLN-ARG-CYS-CYS-ALA-NH2

mhu-conotoxin GIIIB

GEOGRAPHUTOXIN II

GTXII

M-CONOTOXIN GIIIB

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u-Conotoxin GIIIB

Use of u-Conotoxin GIIIB

Names

u-Conotoxin GIIIB Biological Activity

Chemical & Physical Properties

Safety Information

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.