BACE1-IN-13

Modify Date: 2024-01-28 11:04:17

BACE1-IN-13 structure	Common Name	BACE1-IN-13
	CAS Number	1397683-26-9	Molecular Weight	420.40
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₇FN₈O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BACE1-IN-13

BACE1-IN-13 (Compound 36) is an orally active BACE1 inhibitor with an IC50 value of 2.9 nM. BACE1-IN-13 is highly potent in hAβ42 cell (IC50 = 1.3 nM). BACE1-IN-13 has cardiovascularly safty and elicits sustained Aβ42 reduction in mouse and dog animal models[1].

Name	BACE1-IN-13

Description	BACE1-IN-13 (Compound 36) is an orally active BACE1 inhibitor with an IC50 value of 2.9 nM. BACE1-IN-13 is highly potent in hAβ42 cell (IC50 = 1.3 nM). BACE1-IN-13 has cardiovascularly safty and elicits sustained Aβ42 reduction in mouse and dog animal models[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Neurological Disease
Target	IC50: 1.3 nM (hAβ42 cell)[1].
References	[1]. Peschiulli A, et al. A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo. ACS Med Chem Lett. 2021 Dec 1;13(1):76-83.

Molecular Formula	C₂₀H₁₇FN₈O₂
Molecular Weight	420.40

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BACE1-IN-13

Use of BACE1-IN-13

Names

BACE1-IN-13 Biological Activity

Chemical & Physical Properties