BACE1-IN-13

Names

[ CAS No. ]:
1397683-26-9

[ Name ]:
BACE1-IN-13

Biological Activity

[Description]:

BACE1-IN-13 (Compound 36) is an orally active BACE1 inhibitor with an IC50 value of 2.9 nM. BACE1-IN-13 is highly potent in hAβ42 cell (IC50 = 1.3 nM). BACE1-IN-13 has cardiovascularly safty and elicits sustained Aβ42 reduction in mouse and dog animal models[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Beta-secretase
Research Areas >> Neurological Disease

[Target]

IC50: 1.3 nM (hAβ42 cell)[1].


[References]

[1]. Peschiulli A, et al. A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo. ACS Med Chem Lett. 2021 Dec 1;13(1):76-83.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H17FN8O2

[ Molecular Weight ]:
420.40

Related Compounds