APX-115
Modify Date: 2024-01-14 23:41:38
APX-115 structure
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Common Name | APX-115 | ||
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| CAS Number | 1395946-75-4 | Molecular Weight | 315.80 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H18ClN3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of APX-115APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 can protect ovariectomy-induced osteoporosis and type 2 diabetes-induced renal injury. APX-115 effectively prevents kidney injury such as albuminuria, glomerular hypertrophy, tubular injury, podocyte injury, fibrosis, and inflammation as well as oxidative stress in diabetic mice[1]. |
| Name | APX-115 |
|---|
| Description | APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 can protect ovariectomy-induced osteoporosis and type 2 diabetes-induced renal injury. APX-115 effectively prevents kidney injury such as albuminuria, glomerular hypertrophy, tubular injury, podocyte injury, fibrosis, and inflammation as well as oxidative stress in diabetic mice[1]. |
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| Related Catalog | |
| Target |
Ki: 1.08 μM (Nox1), 0.57 μM (Nox2) and 0.63 μM (Nox4)[1] |
| References |
| Molecular Formula | C17H18ClN3O |
|---|---|
| Molecular Weight | 315.80 |