1270084-92-8

1270084-92-8 structure

Name: APX-115 freebase
Chemical Name: APX-115 free base
CAS Number: 1270084-92-8
Molecular Formula: C₁₇H₁₇N₃O
Molecular Weight: 279.34
Catalog: Research Areas Endocrinology
Create Date: 2019-12-09 10:45:18
Modify Date: 2025-08-27 00:23:00
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury[1].

Name	APX-115 free base

Description	APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury[1].
Related Catalog	Research Areas >> Endocrinology
Target	Ki: 1.08 μM (Nox1), 0.57 μM (Nox2) and 0.63 μM (Nox4)[1]
References	[1]. Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232.

Molecular Formula	C₁₇H₁₇N₃O
Molecular Weight	279.34