APX-115
Names
[ CAS No. ]:
1395946-75-4
[ Name ]:
APX-115
Biological Activity
[Description]:
APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 can protect ovariectomy-induced osteoporosis and type 2 diabetes-induced renal injury. APX-115 effectively prevents kidney injury such as albuminuria, glomerular hypertrophy, tubular injury, podocyte injury, fibrosis, and inflammation as well as oxidative stress in diabetic mice[1].
[Related Catalog]:
[Target]
Ki: 1.08 μM (Nox1), 0.57 μM (Nox2) and 0.63 μM (Nox4)[1]
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C17H18ClN3O
[ Molecular Weight ]:
315.80