1395946-75-4

1395946-75-4 structure

Name: APX-115
Chemical Name: APX-115
CAS Number: 1395946-75-4
Molecular Formula: C₁₇H₁₈ClN₃O
Molecular Weight: 315.80
Catalog: Research Areas Inflammation/Immunology
Create Date: 2019-10-08 16:27:52
Modify Date: 2024-01-14 23:41:38
APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 can protect ovariectomy-induced osteoporosis and type 2 diabetes-induced renal injury. APX-115 effectively prevents kidney injury such as albuminuria, glomerular hypertrophy, tubular injury, podocyte injury, fibrosis, and inflammation as well as oxidative stress in diabetic mice[1].

Name	APX-115

Description	APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 can protect ovariectomy-induced osteoporosis and type 2 diabetes-induced renal injury. APX-115 effectively prevents kidney injury such as albuminuria, glomerular hypertrophy, tubular injury, podocyte injury, fibrosis, and inflammation as well as oxidative stress in diabetic mice[1].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	Ki: 1.08 μM (Nox1), 0.57 μM (Nox2) and 0.63 μM (Nox4)[1]
References	[1]. Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232.

Molecular Formula	C₁₇H₁₈ClN₃O
Molecular Weight	315.80