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APX-115 freebase

Names

[ CAS No. ]:
1270084-92-8

[ Name ]:
APX-115 freebase

Biological Activity

[Description]:

APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury[1].

[Related Catalog]:

Research Areas >> Endocrinology

[Target]

Ki: 1.08 μM (Nox1), 0.57 μM (Nox2) and 0.63 μM (Nox4)[1]


[References]

[1]. Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H17N3O

[ Molecular Weight ]:
279.34

Related Compounds