Bromo-PEG6-Boc

Modify Date: 2024-01-10 10:10:12

Bromo-PEG6-Boc Structure
Bromo-PEG6-Boc structure
Common Name Bromo-PEG6-Boc
CAS Number 1393330-41-0 Molecular Weight 473.396
Density 1.2±0.1 g/cm3 Boiling Point 489.9±40.0 °C at 760 mmHg
Molecular Formula C19H37BrO8 Melting Point N/A
MSDS N/A Flash Point 250.1±27.3 °C

 Use of Bromo-PEG6-Boc


Bromo-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Bromo-PEG6-t-butyl ester
Synonym More Synonyms

 Bromo-PEG6-Boc Biological Activity

Description Bromo-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 489.9±40.0 °C at 760 mmHg
Molecular Formula C19H37BrO8
Molecular Weight 473.396
Flash Point 250.1±27.3 °C
Exact Mass 472.167175
LogP 0.60
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.466

 Synonyms

3,6,9,12,15,18-Hexaoxaheneicosan-21-oic acid, 1-bromo-, 1,1-dimethylethyl ester
MFCD22574809
2-Methyl-2-propanyl 1-bromo-3,6,9,12,15,18-hexaoxahenicosan-21-oate