Bromo-PEG6-Boc

Names

[ Name ]:
Bromo-PEG6-Boc

[Synonym ]:
3,6,9,12,15,18-Hexaoxaheneicosan-21-oic acid, 1-bromo-, 1,1-dimethylethyl ester
MFCD22574809
2-Methyl-2-propanyl 1-bromo-3,6,9,12,15,18-hexaoxahenicosan-21-oate

Biological Activity

[Description]:

Bromo-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
489.9±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₃₇BrO₈

[ Molecular Weight ]:
473.396

[ Flash Point ]:
250.1±27.3 °C

[ Exact Mass ]:
472.167175

[ LogP ]:
0.60

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.466

Related Compounds

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