N2'-Deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine
Modify Date: 2024-01-06 19:24:30
![N2'-Deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine Structure](https://www.chemsrc.com/caspic/369/138148-68-2.png)
N2'-Deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine structure
|
Common Name | N2'-Deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine | ||
|---|---|---|---|---|
| CAS Number | 138148-68-2 | Molecular Weight | 784.37900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C36H50ClN3O10S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of N2'-Deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansineDM1-SMe is an unconjugated form of the Maytansinoid in IMGN901. DM1-SMe is about 3-10-fold more potent than the parent drug Maytansine, with IC50s ranging from 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines[1]. |
| Name | N2'-deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine |
|---|---|
| Synonym | More Synonyms |
| Description | DM1-SMe is an unconjugated form of the Maytansinoid in IMGN901. DM1-SMe is about 3-10-fold more potent than the parent drug Maytansine, with IC50s ranging from 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines[1]. |
|---|---|
| Related Catalog | |
| Target |
Maytansinoids |
| References |
| Molecular Formula | C36H50ClN3O10S2 |
|---|---|
| Molecular Weight | 784.37900 |
| Exact Mass | 783.26300 |
| PSA | 207.07000 |
| LogP | 5.30960 |
| Precursor 0 | |
|---|---|
| DownStream 1 | |
CAS#:139504-50-0| Maytansinoid DM1 |
| Mertansine |