138148-68-2

138148-68-2 structure

Name: N2'-Deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine
Chemical Name: N2'-deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine
CAS Number: 138148-68-2
Molecular Formula: C₃₆H₅₀ClN₃O₁₀S₂
Molecular Weight: 784.37900
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2018-07-18 11:11:07
Modify Date: 2025-08-25 16:50:09
DM1-SMe is an unconjugated form of the Maytansinoid in IMGN901. DM1-SMe is about 3-10-fold more potent than the parent drug Maytansine, with IC50s ranging from 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines[1].

Name	N2'-deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine
Synonyms	Maytansinoid DM1 Mertansine

Description	DM1-SMe is an unconjugated form of the Maytansinoid in IMGN901. DM1-SMe is about 3-10-fold more potent than the parent drug Maytansine, with IC50s ranging from 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	Maytansinoids
References	[1]. Wood AC, et al. Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program. Pediatr Blood Cancer. 2013;60(11):1860-1867. [2]. Chari RV. Targeted cancer therapy: conferring specificity to cytotoxic drugs. Acc Chem Res. 2008;41(1):98-107.

Precursor 0
DownStream 1
139504-50-0