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N2'-Deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine

Names

[ CAS No. ]:
138148-68-2

[ Name ]:
N2'-Deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine

[Synonym ]:
Maytansinoid DM1
Mertansine

Biological Activity

[Description]:

DM1-SMe is an unconjugated form of the Maytansinoid in IMGN901. DM1-SMe is about 3-10-fold more potent than the parent drug Maytansine, with IC50s ranging from 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

Maytansinoids


[References]

[1]. Wood AC, et al. Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program. Pediatr Blood Cancer. 2013;60(11):1860-1867.

[2]. Chari RV. Targeted cancer therapy: conferring specificity to cytotoxic drugs. Acc Chem Res. 2008;41(1):98-107.

Chemical & Physical Properties

[ Molecular Formula ]:
C36H50ClN3O10S2

[ Molecular Weight ]:
784.37900

[ Exact Mass ]:
783.26300

[ PSA ]:
207.07000

[ LogP ]:
5.30960

Precursor & DownStream

Precursor

DownStream