Mertansine

Modify Date: 2024-01-02 14:08:44

Mertansine structure	Common Name	Mertansine
	CAS Number	139504-50-0	Molecular Weight	738.288
	Density	1.33±0.1 g/cm3	Boiling Point	937.1±65.0 °C at 760 mmHg
	Molecular Formula	C₃₅H₄₈ClN₃O₁₀S	Melting Point	190-192 ºC
	MSDS	N/A	Flash Point	520.5±34.3 °C

Use of Mertansine

Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery.

Name	Mertansine
Synonym	More Synonyms

Description	Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery.
Related Catalog	Signaling Pathways >> Antibody-drug Conjugate >> Drug-Linker Conjugates for ADC Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Cancer
References	[1]. Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules.

Density	1.33±0.1 g/cm3
Boiling Point	937.1±65.0 °C at 760 mmHg
Melting Point	190-192 ºC
Molecular Formula	C₃₅H₄₈ClN₃O₁₀S
Molecular Weight	738.288
Flash Point	520.5±34.3 °C
Exact Mass	737.274902
PSA	198.76000
LogP	4.76
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.599
Storage condition	-20℃
Water Solubility	Insuluble (2.4E-4 g/L) (25 ºC)

N2'-Deacetyl-N2...

CAS#:138148-68-2

~75%

Mertansine

CAS#:139504-50-0

Literature: Widdison, Wayne C.; Wilhelm, Sharon D.; Cavanagh, Emily E.; Whiteman, Kathleen R.; Leece, Barbara A.; Kovtun, Yelena; Goldmacher, Victor S.; Xie, Hongsheng; Steeves, Rita M.; Lutz, Robert J.; Zhao, Robert; Wang, Lintao; Blaettler, Walter A.; Chari, Ravi V. J. Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4392 - 4408

(S)-2-(N-Methyl...

CAS#:138148-62-6

Mertansine

CAS#:139504-50-0

Literature: Journal of Medicinal Chemistry, , vol. 49, # 14 p. 4392 - 4408

Maytansinol

CAS#:57103-68-1

Mertansine

CAS#:139504-50-0

Literature: Journal of Medicinal Chemistry, , vol. 49, # 14 p. 4392 - 4408

Precursor 3
CAS#:138148-68-2 N2'-Deacetyl-N2... CAS#:138148-62-6 (S)-2-(N-Methyl... CAS#:57103-68-1 Maytansinol
DownStream 0

UNII-DDZ29HGH0E

DM1 Compound

DM1 [Maytansinoid]

(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-Chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2 S)-2-[methyl(3-sulfanylpropanoyl)amino]propanoate (non-preferred name)

Maytansine,N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)

DM 1

Mertansine

maytansinoid DM1

N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine

maytansinoid DM 1

N2'-deacetyl-N2'-(3-Mercapto-1-oxopropyl)-Maytansine

DC Chemicals Limited
China
Product Name: DM-1(Mertansine)
Price: $400.0/50mg $700.0/100mg $1200.0/250mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Mertansine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: N2'-deacetyl-N2'-(3-Mercapto-1-oxopropyl)-Maytansine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: $172/10mM*1mLinDMSO

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Mertansine

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