Mertansine
Modify Date: 2025-08-20 22:02:55
Mertansine structure
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Common Name | Mertansine | ||
|---|---|---|---|---|
| CAS Number | 139504-50-0 | Molecular Weight | 738.288 | |
| Density | 1.33±0.1 g/cm3 | Boiling Point | 937.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C35H48ClN3O10S | Melting Point | 190-192 ºC | |
| MSDS | N/A | Flash Point | 520.5±34.3 °C | |
Use of MertansineMertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. |
| Name | Mertansine |
|---|---|
| Synonym | More Synonyms |
| Description | Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.33±0.1 g/cm3 |
|---|---|
| Boiling Point | 937.1±65.0 °C at 760 mmHg |
| Melting Point | 190-192 ºC |
| Molecular Formula | C35H48ClN3O10S |
| Molecular Weight | 738.288 |
| Flash Point | 520.5±34.3 °C |
| Exact Mass | 737.274902 |
| PSA | 198.76000 |
| LogP | 4.76 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.599 |
| InChIKey | ANZJBCHSOXCCRQ-OQIPERMCSA-N |
| SMILES | COc1cc2cc(c1Cl)N(C)C(=O)CC(OC(=O)C(C)N(C)C(=O)CCS)C1(C)OC1C(C)C1CC(O)(NC(=O)O1)C(OC)C=CC=C(C)C2 |
| Storage condition | -20℃ |
| Water Solubility | Insuluble (2.4E-4 g/L) (25 ºC) |
|
~75%
Mertansine CAS#:139504-50-0 |
| Literature: Widdison, Wayne C.; Wilhelm, Sharon D.; Cavanagh, Emily E.; Whiteman, Kathleen R.; Leece, Barbara A.; Kovtun, Yelena; Goldmacher, Victor S.; Xie, Hongsheng; Steeves, Rita M.; Lutz, Robert J.; Zhao, Robert; Wang, Lintao; Blaettler, Walter A.; Chari, Ravi V. J. Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4392 - 4408 |
|
~%
Mertansine CAS#:139504-50-0 |
| Literature: Journal of Medicinal Chemistry, , vol. 49, # 14 p. 4392 - 4408 |
|
~%
Mertansine CAS#:139504-50-0 |
| Literature: Journal of Medicinal Chemistry, , vol. 49, # 14 p. 4392 - 4408 |
![N2'-Deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine structure](https://image.chemsrc.com/caspic/369/138148-68-2.png)
| Precursor 3 | |
|---|---|
| DownStream 0 | |
| UNII-DDZ29HGH0E |
| DM1 Compound |
| DM1 [Maytansinoid] |
| (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-Chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2 S)-2-[methyl(3-sulfanylpropanoyl)amino]propanoate (non-preferred name) |
| Maytansine,N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl) |
| DM 1 |
| Mertansine |
| maytansinoid DM1 |
| N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine |
| maytansinoid DM 1 |
| N2'-deacetyl-N2'-(3-Mercapto-1-oxopropyl)-Maytansine |