KML 29

Modify Date: 2024-01-09 11:44:49

KML 29 structure	Common Name	KML 29
	CAS Number	1380424-42-9	Molecular Weight	549.417
	Density	1.5±0.1 g/cm3	Boiling Point	554.8±50.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₂₁F₆NO₇	Melting Point	N/A
	MSDS	N/A	Flash Point	289.3±30.1 °C

Use of KML 29

KML29 is a potent and selective MAGL inhibitor with IC50 = 5.9, 15, and 43 nM in human, mouse, and rat brain proteomes, respectively.IC50 value: 15, 43, and 5.9 nM (mouse, rat, and human brain proteomes)Target: MAGLin vitro: KML29 potently and selectively inhibits MAGL with minimal cross-reactivity toward other central and peripheral serine hydrolases, including no detectable activity against FAAH.[1]in vivo: KML29 a potentially very useful tool to explore the consequences of inhibiting MAGL in the whole animal and in multiple species, and provides greater selectivity than JZL184 in inhibiting MAGL. [2]

Name	1,1,1,3,3,3-Hexafluoro-2-propanyl 4-[bis(1,3-benzodioxol-5-yl)(hy droxy)methyl]-1-piperidinecarboxylate
Synonym	More Synonyms

Description	KML29 is a potent and selective MAGL inhibitor with IC50 = 5.9, 15, and 43 nM in human, mouse, and rat brain proteomes, respectively.IC50 value: 15, 43, and 5.9 nM (mouse, rat, and human brain proteomes)Target: MAGLin vitro: KML29 potently and selectively inhibits MAGL with minimal cross-reactivity toward other central and peripheral serine hydrolases, including no detectable activity against FAAH.[1]in vivo: KML29 a potentially very useful tool to explore the consequences of inhibiting MAGL in the whole animal and in multiple species, and provides greater selectivity than JZL184 in inhibiting MAGL. [2]
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL Research Areas >> Metabolic Disease
References	[1]. Chang JW, et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol. 2012 May 25;19(5):579-588. [2]. Ignatowska-Jankowska BM,et al. In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects. Br J Pharmacol. 2014 Mar;171(6):1392-1407.

Description

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL

Research Areas >> Metabolic Disease

References

[1]. Chang JW, et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol. 2012 May 25;19(5):579-588.

[2]. Ignatowska-Jankowska BM,et al. In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects. Br J Pharmacol. 2014 Mar;171(6):1392-1407.

Density	1.5±0.1 g/cm3
Boiling Point	554.8±50.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₁F₆NO₇
Molecular Weight	549.417
Flash Point	289.3±30.1 °C
Exact Mass	549.122192
PSA	86.69000
LogP	6.05
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.544
Storage condition	2-8℃

Precursor 5
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