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KML 29

Names

[ CAS No. ]:
1380424-42-9

[ Name ]:
KML 29

[Synonym ]:
1,1,1,3,3,3-hexafluoroprop-2-yl acrylate
1,1,1,3,3,3-hexafluoropropan-2-yl acrylate
Acrylic Acid 1,1,1,3,3,3-Hexafluoroisopropyl Ester
1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
hexafluoro-2-propyl acrylate
Hexafluoroisopropyl acrylate
1,1,1,3,3,3-Hexafluoro-2-propanyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]-1-piperidinecarboxylate
1,1,1,3,3,3-hexafluoroisopropylacrylate
KML-29
KML29

Biological Activity

[Description]:

KML29 is a potent and selective MAGL inhibitor with IC50 = 5.9, 15, and 43 nM in human, mouse, and rat brain proteomes, respectively.IC50 value: 15, 43, and 5.9 nM (mouse, rat, and human brain proteomes)Target: MAGLin vitro: KML29 potently and selectively inhibits MAGL with minimal cross-reactivity toward other central and peripheral serine hydrolases, including no detectable activity against FAAH.[1]in vivo: KML29 a potentially very useful tool to explore the consequences of inhibiting MAGL in the whole animal and in multiple species, and provides greater selectivity than JZL184 in inhibiting MAGL. [2]

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL
Research Areas >> Metabolic Disease

[References]

[1]. Chang JW, et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol. 2012 May 25;19(5):579-588.

[2]. Ignatowska-Jankowska BM,et al. In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects. Br J Pharmacol. 2014 Mar;171(6):1392-1407.


[Related Small Molecules]

JZL184 | JZL195 | WWL 70 | JW 642 | ABX-1431 | JJKK 048

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
554.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H21F6NO7

[ Molecular Weight ]:
549.417

[ Flash Point ]:
289.3±30.1 °C

[ Exact Mass ]:
549.122192

[ PSA ]:
86.69000

[ LogP ]:
6.05

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.544

[ Storage condition ]:
2-8℃

Precursor & DownStream

Precursor

DownStream

Related Compounds