<Suppliers Price>

JJKK 048

Names

[ CAS No. ]:
1515855-97-6

[ Name ]:
JJKK 048

[Synonym ]:
{4-[Bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl}(1H-1,2,4-triazol-1-yl)methanone
Methanone, [4-[bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl]-1H-1,2,4-triazol-1-yl-

Biological Activity

[Description]:

JJKK 048 is an ultrapotent and highly selective inhibitor of Monoacylglycerol lipase (MAGL).

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL
Research Areas >> Neurological Disease

[Target]

MAGL[1]


[References]

[1]. Aaltonen N, et al. In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048). J Pharmacol Exp Ther. 2016 Oct;359(1):62-72.

[2]. Aaltonen N, et al. Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. Chem Biol. 2013 Mar 21;20(3):379-90.


[Related Small Molecules]

JZL184 | JZL195 | WWL 70 | KML 29 | JW 642 | ABX-1431

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
615.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H22N4O5

[ Molecular Weight ]:
434.445

[ Flash Point ]:
326.3±34.3 °C

[ Exact Mass ]:
434.159027

[ LogP ]:
2.47

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.727

[ Storage condition ]:
2-8℃

Related Compounds