APY 29
Modify Date: 2024-01-08 18:52:12
APY 29 structure
|
Common Name | APY 29 | ||
|---|---|---|---|---|
| CAS Number | 1216665-49-4 | Molecular Weight | 332.362 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 782.3±70.0 °C at 760 mmHg | |
| Molecular Formula | C17H16N8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 426.9±35.7 °C | |
Use of APY 29APY29 is an allosteric modulator of IRE1α which inhibits IRE1α autophosphorylation with IC50 of 280 nM and activates IRE1α RNase activity. |
| Name | apy29 |
|---|---|
| Synonym | More Synonyms |
| Description | APY29 is an allosteric modulator of IRE1α which inhibits IRE1α autophosphorylation with IC50 of 280 nM and activates IRE1α RNase activity. |
|---|---|
| Related Catalog | |
| Target |
IC50: 280 nM (IRE1α) |
| In Vitro | APY29 divergently modulates the RNase activity and oligomerization state of IRE1α. APY29 is exerting their opposing effects on RNase activity through the same binding site. APY29 divergently affects IRE1α oligomerization. APY29 demonstrates opposing dose-dependent effects on ER stress-induced activation of the RNase of endogenous IRE1α[1]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 782.3±70.0 °C at 760 mmHg |
| Molecular Formula | C17H16N8 |
| Molecular Weight | 332.362 |
| Flash Point | 426.9±35.7 °C |
| Exact Mass | 332.149780 |
| PSA | 107.20000 |
| LogP | 1.66 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.861 |
| Storage condition | 2-8℃ |
| 2,4-Pyrimidinediamine, N-1H-benzimidazol-5-yl-N-(3-cyclopropyl-1H-pyrazol-5-yl)- |
| N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine |
| N-(1H-Benzimidazol-5-yl)-N-(3-cyclopropyl-1H-pyrazol-5-yl)-2,4-pyrimidinediamine |