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  • DC Chemicals Limited
  • China
  • Product Name: APY29
  • Price: $450.0/100mg $850.0/250mg $1700.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

1216665-49-4

1216665-49-4 structure
1216665-49-4 structure
  • Name: APY 29
  • Chemical Name: apy29
  • CAS Number: 1216665-49-4
  • Molecular Formula: C17H16N8
  • Molecular Weight: 332.362
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage IRE1
  • Create Date: 2017-04-17 11:41:24
  • Modify Date: 2024-01-08 18:52:12
  • APY29 is an allosteric modulator of IRE1α which inhibits IRE1α autophosphorylation with IC50 of 280 nM and activates IRE1α RNase activity.

Name apy29
Synonyms 2,4-Pyrimidinediamine, N-1H-benzimidazol-5-yl-N-(3-cyclopropyl-1H-pyrazol-5-yl)-
N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
N-(1H-Benzimidazol-5-yl)-N-(3-cyclopropyl-1H-pyrazol-5-yl)-2,4-pyrimidinediamine
Description APY29 is an allosteric modulator of IRE1α which inhibits IRE1α autophosphorylation with IC50 of 280 nM and activates IRE1α RNase activity.
Related Catalog
Target

IC50: 280 nM (IRE1α)

In Vitro APY29 divergently modulates the RNase activity and oligomerization state of IRE1α. APY29 is exerting their opposing effects on RNase activity through the same binding site. APY29 divergently affects IRE1α oligomerization. APY29 demonstrates opposing dose-dependent effects on ER stress-induced activation of the RNase of endogenous IRE1α[1].
References

[1]. Wang L, et al. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012 Dec;8(12):982-9.

Density 1.6±0.1 g/cm3
Boiling Point 782.3±70.0 °C at 760 mmHg
Molecular Formula C17H16N8
Molecular Weight 332.362
Flash Point 426.9±35.7 °C
Exact Mass 332.149780
PSA 107.20000
LogP 1.66
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.861
Storage condition 2-8℃