JMS-17-2

Modify Date: 2025-08-25 18:50:30

JMS-17-2 Structure
JMS-17-2 structure
Common Name JMS-17-2
CAS Number 1380392-05-1 Molecular Weight 419.95
Density 1.3±0.1 g/cm3 Boiling Point 603.8±55.0 °C at 760 mmHg
Molecular Formula C25H26ClN3O Melting Point N/A
MSDS N/A Flash Point 319.0±31.5 °C

 Use of JMS-17-2


JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM[1].

 Names

Name 5-{3-[4-(4-Chlorophenyl)-1-piperidinyl]propyl}pyrrolo[1,2-a]quinoxalin-4(5H)-one
Synonym More Synonyms

 JMS-17-2 Biological Activity

Description JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM[1].
Related Catalog
Target

CX3CR1:0.32 nM (IC50)

References

[1]. Shen F, et al. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol Cancer Res. 2016 Jun;14(6):518-27.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 603.8±55.0 °C at 760 mmHg
Molecular Formula C25H26ClN3O
Molecular Weight 419.95
Flash Point 319.0±31.5 °C
Exact Mass 419.176453
LogP 4.80
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.661

 Synonyms

5-{3-[4-(4-Chlorophenyl)-1-piperidinyl]propyl}pyrrolo[1,2-a]quinoxalin-4(5H)-one
Pyrrolo[1,2-a]quinoxalin-4(5H)-one, 5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]-
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