JMS-17-2

Names

[ Name ]:
JMS-17-2

[Synonym ]:
5-{3-[4-(4-Chlorophenyl)-1-piperidinyl]propyl}pyrrolo[1,2-a]quinoxalin-4(5H)-one
Pyrrolo[1,2-a]quinoxalin-4(5H)-one, 5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]-

Biological Activity

[Description]:

JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> CXCR

Signaling Pathways >> Immunology/Inflammation >> CXCR

[Target]

CX3CR1:0.32 nM (IC50)

[References]

[1]. Shen F, et al. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol Cancer Res. 2016 Jun;14(6):518-27.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
603.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₂₆ClN₃O

[ Molecular Weight ]:
419.95

[ Flash Point ]:
319.0±31.5 °C

[ Exact Mass ]:
419.176453

[ LogP ]:
4.80

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.661

Related Compounds

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