A-17

Names

[ Name ]:
A-17

[Synonym ]:
2-{[4-(2-Furyl)-6-(trifluoromethyl)-2-pyrimidinyl]sulfanyl}-N-(5-methyl-1,2-oxazol-3-yl)acetamide
Acetamide, 2-[[4-(2-furanyl)-6-(trifluoromethyl)-2-pyrimidinyl]thio]-N-(5-methyl-3-isoxazolyl)-
2-{[4-(2-Furyl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl}-N-(5-methyl-1,2-oxazol-3-yl)acetamide
2-[[4-(2-furanyl)-6-(trifluoromethyl)-2-pyrimidinyl]thio]-N-(5-methyl-3-isoxazolyl)acetamide

Biological Activity

[Description]:

A potent Hsp90α/p23 interaction inhibitor with IC50 of 0.15 uM, more effective than CP-9 in degrading pAkt/total Akt and Raf-1; inhibits Hsp90(α/β)/p23 interactions and degrading Hsp90 client proteins in cell culture, but not in live mice.

[References]

References 1. Chan CT, et al. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2476-85. View Related Products by Target Heat Shock Protein (HSP)

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
579.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₁F₃N₄O₃S

[ Molecular Weight ]:
384.333

[ Flash Point ]:
304.2±30.1 °C

[ Exact Mass ]:
384.050385

[ LogP ]:
2.81

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.593

Related Compounds

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