A-17
Modify Date: 2023-05-20 11:10:19
A-17 structure
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Common Name | A-17 | ||
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| CAS Number | 505057-98-7 | Molecular Weight | 384.333 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 579.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C15H11F3N4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 304.2±30.1 °C | |
Use of A-17A potent Hsp90α/p23 interaction inhibitor with IC50 of 0.15 uM, more effective than CP-9 in degrading pAkt/total Akt and Raf-1; inhibits Hsp90(α/β)/p23 interactions and degrading Hsp90 client proteins in cell culture, but not in live mice. |
| Name | 2-[[4-(2-furanyl)-6-(trifluoromethyl)-2-pyrimidinyl]thio]-N-(5-methyl-3-isoxazolyl)acetamide |
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| Synonym | More Synonyms |
| Description | A potent Hsp90α/p23 interaction inhibitor with IC50 of 0.15 uM, more effective than CP-9 in degrading pAkt/total Akt and Raf-1; inhibits Hsp90(α/β)/p23 interactions and degrading Hsp90 client proteins in cell culture, but not in live mice. |
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| References | References 1. Chan CT, et al. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2476-85. View Related Products by Target Heat Shock Protein (HSP) |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 579.4±50.0 °C at 760 mmHg |
| Molecular Formula | C15H11F3N4O3S |
| Molecular Weight | 384.333 |
| Flash Point | 304.2±30.1 °C |
| Exact Mass | 384.050385 |
| LogP | 2.81 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.593 |
| 2-{[4-(2-Furyl)-6-(trifluoromethyl)-2-pyrimidinyl]sulfanyl}-N-(5-methyl-1,2-oxazol-3-yl)acetamide |
| Acetamide, 2-[[4-(2-furanyl)-6-(trifluoromethyl)-2-pyrimidinyl]thio]-N-(5-methyl-3-isoxazolyl)- |
| 2-{[4-(2-Furyl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl}-N-(5-methyl-1,2-oxazol-3-yl)acetamide |
| 2-[[4-(2-furanyl)-6-(trifluoromethyl)-2-pyrimidinyl]thio]-N-(5-methyl-3-isoxazolyl)acetamide |