Trimethobenzamide
Modify Date: 2024-01-03 16:46:15
Trimethobenzamide structure
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Common Name | Trimethobenzamide | ||
|---|---|---|---|---|
| CAS Number | 138-56-7 | Molecular Weight | 388.45700 | |
| Density | 1.131 g/cm3 | Boiling Point | 506.9ºC at 760 mmHg | |
| Molecular Formula | C21H28N2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 260.4ºC | |
Use of TrimethobenzamideTrimethobenzamide (Ro 2-9578 free base) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting[1]. |
| Name | N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide |
|---|---|
| Synonym | More Synonyms |
| Description | Trimethobenzamide (Ro 2-9578 free base) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting[1]. |
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| Related Catalog | |
| Target |
D2 receptor[1] |
| In Vitro | Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center[1]. |
| In Vivo | The oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration[1]. |
| References |
[1]. Smith HS, et al. Dopamine receptor antagonists. Ann Palliat Med. 2012 Jul;1(2):137-42. |
| Density | 1.131 g/cm3 |
|---|---|
| Boiling Point | 506.9ºC at 760 mmHg |
| Molecular Formula | C21H28N2O5 |
| Molecular Weight | 388.45700 |
| Flash Point | 260.4ºC |
| Exact Mass | 388.20000 |
| PSA | 69.26000 |
| LogP | 2.97370 |
| Vapour Pressure | 2.13E-10mmHg at 25°C |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2924299090 |
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Trimethobenzamide CAS#:138-56-7 |
| Literature: US2879293 , ; |
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Trimethobenzamide CAS#:138-56-7 |
| Literature: US2879293 , ; |
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Trimethobenzamide CAS#:138-56-7 |
| Literature: US2879293 , ; |
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Trimethobenzamide CAS#:138-56-7 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 40, # 1 p. 202 - 211 |
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Trimethobenzamide CAS#:138-56-7 |
| Literature: Organic Process Research and Development, , vol. 17, # 7 p. 981 - 984 |
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Trimethobenzamide CAS#:138-56-7 |
| Literature: Organic Process Research and Development, , vol. 17, # 7 p. 981 - 984 |
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Trimethobenzamide CAS#:138-56-7
Detail
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| Literature: Organic Process Research and Development, , vol. 17, # 7 p. 981 - 984 |
![4-[2-(dimethylamino)ethoxy]benzylamine structure](https://www.chemsrc.com/caspic/350/20059-73-8.png)
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| Tebamide |
| Trimethobenzamid |
| EINECS 205-332-1 |
| Trimethobenzamidum |
| Trimazide |
| Benzacot |
| trimethobenzamide |
| Tribenzagan |
| Tigan |
| Stemetic |
| Trimetobenzamida |