Trimethobenzamide

Names

[ CAS No. ]:
138-56-7

[ Name ]:
Trimethobenzamide

[Synonym ]:
Tebamide
Trimethobenzamid
EINECS 205-332-1
Trimethobenzamidum
Trimazide
Benzacot
trimethobenzamide
Tribenzagan
Tigan
Stemetic
Trimetobenzamida

Biological Activity

[Description]:

Trimethobenzamide (Ro 2-9578 free base) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[Target]

D2 receptor[1]

[In Vitro]

Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center[1].

[In Vivo]

The oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration[1].

[References]

[1]. Smith HS, et al. Dopamine receptor antagonists. Ann Palliat Med. 2012 Jul;1(2):137-42.

Chemical & Physical Properties

[ Density]:
1.131 g/cm3

[ Boiling Point ]:
506.9ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₈N₂O₅

[ Molecular Weight ]:
388.45700

[ Flash Point ]:
260.4ºC

[ Exact Mass ]:
388.20000

[ PSA ]:
69.26000

[ LogP ]:
2.97370

[ Vapour Pressure ]:
2.13E-10mmHg at 25°C

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.