GR 64349
GR 64349 structure
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Common Name | GR 64349 | ||
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| CAS Number | 137593-52-3 | Molecular Weight | 921.11500 | |
| Density | 1.31g/cm3 | Boiling Point | 1342.8ºC at 760mmHg | |
| Molecular Formula | C42H68N10O11S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 765.9ºC | |
Use of GR 64349GR 64349 is a potent and highly selective NK2 receptor peptide antagonist, with an EC50 of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK1 and NK3 receptors, respectively[1][2]. |
| Name | L-lysyl-L-α-aspartyl-L-seryl-L-phenylalanyl-L-valyl-(αS,3R)-3-amino-α-(2-methylpropyl)-2-oxo-1-pyrrolidineacetyl-L-methioninamide |
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| Synonym | More Synonyms |
| Description | GR 64349 is a potent and highly selective NK2 receptor peptide antagonist, with an EC50 of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK1 and NK3 receptors, respectively[1][2]. |
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| Related Catalog | |
| References |
| Density | 1.31g/cm3 |
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| Boiling Point | 1342.8ºC at 760mmHg |
| Molecular Formula | C42H68N10O11S |
| Molecular Weight | 921.11500 |
| Flash Point | 765.9ºC |
| Exact Mass | 920.47900 |
| PSA | 372.87000 |
| LogP | 1.98680 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Endogenous modulation of excitatory amino acid responsiveness by tachykinin NK1 and NK2 receptors in the rat spinal cord.
Br. J. Pharmacol. 115(6) , 1013-9, (1995) 1. The effects of selective tachykinin (neurokinin, NK) NK1 and NK2 receptor antagonists have been examined on spinal neurones in alpha-chloralose anaesthetized, spinalized rats. They were tested for ... |
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Tachykinin receptor types: Classification and membrane signalling mechanisms.
Neurochem. Int. 18 , 149-165, (1991) The use of selective agonists in both functional and binding studies has provided unequivocal evidence for the existence of three types of tachykinin receptor (NK(1), NK(2) and NK(3)); there is also p... |
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Receptor-selective, peptidase-resistant agonists at neurokinin NK-1 and NK-2 receptors: new tools for investigating neurokinin function.
Neuropeptides 19 , 127-135, (1991) The pharmacological profiles of two novel neurokinin agonists have been investigated. delta Ava[L-Pro9,N-MeLeu10]SP(7-11) (GR73632) and [Lys3,Gly8-R-gamma-lactam-Leu9] NKA(3-10) (GR64349) are potent a... |
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