GR 159897
Modify Date: 2025-09-05 07:31:06
GR 159897 structure
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Common Name | GR 159897 | ||
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| CAS Number | 158848-32-9 | Molecular Weight | 414.54 | |
| Density | 1.29g/cm3 | Boiling Point | 600.2ºC at 760mmHg | |
| Molecular Formula | C23H27FN2O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 316.8ºC | |
Use of GR 159897GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide antagonist at tachykinin NK2 receptors, inhibits binding of [3H]GR100679 to hNK2-CHO cells and rat colon membranes with pKis of 9.51 and 10, respectively. Antagonizes bronchoconstriction, with anxiolytic-like activity[1]. |
| Name | 3-[2-[4-(benzenesulfinylmethyl)-4-methoxypiperidin-1-yl]ethyl]-5-fluoro-1H-indole |
|---|---|
| Synonym | More Synonyms |
| Description | GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide antagonist at tachykinin NK2 receptors, inhibits binding of [3H]GR100679 to hNK2-CHO cells and rat colon membranes with pKis of 9.51 and 10, respectively. Antagonizes bronchoconstriction, with anxiolytic-like activity[1]. |
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| Related Catalog | |
| Target |
NK2:10 (pKi, Rat colon membrane) hNK2:9.51 (pKi, CHO cell) |
| References |
| Density | 1.29g/cm3 |
|---|---|
| Boiling Point | 600.2ºC at 760mmHg |
| Molecular Formula | C23H27FN2O2S |
| Molecular Weight | 414.54 |
| Flash Point | 316.8ºC |
| Exact Mass | 414.17800 |
| PSA | 64.54000 |
| LogP | 4.94190 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.656 |
| WGK Germany | 3 |
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| Tocris-1274 |
| Agitoxin 2 |
| HMS3267L05 |