Dmt-2'fluoro-da(bz) amidite

Modify Date: 2024-01-07 14:13:07

Dmt-2'fluoro-da(bz) amidite Structure
Dmt-2'fluoro-da(bz) amidite structure
Common Name Dmt-2'fluoro-da(bz) amidite
CAS Number 136834-22-5 Molecular Weight 875.923
Density N/A Boiling Point N/A
Molecular Formula C47H51FN7O7P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Dmt-2'fluoro-da(bz) amidite


Dmt-2'fluoro-da(bz) amidite, an uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotide, is a nuclease-resistant antisense compound with high affinity and specificity for RNA targets. Dmt-2'fluoro-da(bz) amidite is also an intermediate for 5’-DMT-3’-phosphoramidite synthesis[1].

 Names

Name N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-deoxy-2'-fluoroadenosine
Synonym More Synonyms

 Dmt-2'fluoro-da(bz) amidite Biological Activity

Description Dmt-2'fluoro-da(bz) amidite, an uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotide, is a nuclease-resistant antisense compound with high affinity and specificity for RNA targets. Dmt-2'fluoro-da(bz) amidite is also an intermediate for 5’-DMT-3’-phosphoramidite synthesis[1].
Related Catalog
References

[1]. Kawasaki AM, et, al. Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets. J Med Chem. 1993 Apr 2;36(7):831-41.

 Chemical & Physical Properties

Molecular Formula C47H51FN7O7P
Molecular Weight 875.923
Exact Mass 875.357178
LogP 10.49

 Safety Information

Hazard Codes Xi

 Synonyms

N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-deoxy-2'-fluoroadenosine
Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2'-deoxy-2'-fluoro-