MK2-IN-28
Modify Date: 2024-04-05 13:32:56
MK2-IN-28 structure
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Common Name | MK2-IN-28 | ||
|---|---|---|---|---|
| CAS Number | 1355617-50-3 | Molecular Weight | 569.665 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C35H31N5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MK2-IN-28A potent and selective, non-ATP competitive, allosteric MAPKAPK2/3 (MK2/3) inhibitor with IC50 of 8 nM for MK2, hTNFα EC50 of 0.31 uM; inhibits both MK2 and MK3, and has no or little effect on the other kinases; ameliorates glucose homeostasis by suppressing excessive HGP and enhancing insulin signaling in obese mice. |
| Name | MK2-IN-28 |
|---|
| Description | A potent and selective, non-ATP competitive, allosteric MAPKAPK2/3 (MK2/3) inhibitor with IC50 of 8 nM for MK2, hTNFα EC50 of 0.31 uM; inhibits both MK2 and MK3, and has no or little effect on the other kinases; ameliorates glucose homeostasis by suppressing excessive HGP and enhancing insulin signaling in obese mice. |
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| References | References 1. Huang X, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):65-70. 2. Ozcan L, et al. Diabetes. 2015 Oct;64(10):3396-405. View Related Products by Target MAPKAPK2 (MK2) |
| Molecular Formula | C35H31N5O3 |
|---|---|
| Molecular Weight | 569.665 |