1355617-50-3
1355617-50-3 structure
- Name: MK2-IN-28
- Chemical Name: MK2-IN-28
- CAS Number: 1355617-50-3
- Molecular Formula: C35H31N5O3
- Molecular Weight: 569.665
- Create Date: 2020-01-11 21:13:19
- Modify Date: 2024-04-05 13:32:56
-
A potent and selective, non-ATP competitive, allosteric MAPKAPK2/3 (MK2/3) inhibitor with IC50 of 8 nM for MK2, hTNFα EC50 of 0.31 uM; inhibits both MK2 and MK3, and has no or little effect on the other kinases; ameliorates glucose homeostasis by suppressing excessive HGP and enhancing insulin signaling in obese mice.
| Name | MK2-IN-28 |
|---|
| Description | A potent and selective, non-ATP competitive, allosteric MAPKAPK2/3 (MK2/3) inhibitor with IC50 of 8 nM for MK2, hTNFα EC50 of 0.31 uM; inhibits both MK2 and MK3, and has no or little effect on the other kinases; ameliorates glucose homeostasis by suppressing excessive HGP and enhancing insulin signaling in obese mice. |
|---|---|
| References | References 1. Huang X, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):65-70. 2. Ozcan L, et al. Diabetes. 2015 Oct;64(10):3396-405. View Related Products by Target MAPKAPK2 (MK2) |
| Molecular Formula | C35H31N5O3 |
|---|---|
| Molecular Weight | 569.665 |