2747100-02-1

2747100-02-1 structure

Name: PI3K-IN-28
Chemical Name: PI3K-IN-28
CAS Number: 2747100-02-1
Molecular Formula: C₂₆H₁₆F₉N₃O₃S₂
Molecular Weight: 653.54
Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
Create Date: 2022-07-01 21:31:47
Modify Date: 2024-01-10 18:52:44
PI3K-IN-28 (Compound 6c) is a potent inhibitor of PI3K. PI3K-IN-28 displays the most potent activity with lower toxic effects on MCF-10a. PI3K-IN-28 displays half-maximal inhibitory concentration (IC50, μM) values of 5.8, 2.3, and 7.9. PI3K-IN-28 is the most potent one with a selectivity index (SI) of 39 and is considered as a latent lead for further optimization of anticancer agents[1].

Name	PI3K-IN-28

Description	PI3K-IN-28 (Compound 6c) is a potent inhibitor of PI3K. PI3K-IN-28 displays the most potent activity with lower toxic effects on MCF-10a. PI3K-IN-28 displays half-maximal inhibitory concentration (IC50, μM) values of 5.8, 2.3, and 7.9. PI3K-IN-28 is the most potent one with a selectivity index (SI) of 39 and is considered as a latent lead for further optimization of anticancer agents[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
References	[1]. Tantawy AH, et al. Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Fluorinated Candidates as PI3K Inhibitors: Targeting Fluorophilic Binding Sites. J Med Chem. 2021 Dec 9;64(23):17468-17485.

Molecular Formula	C₂₆H₁₆F₉N₃O₃S₂
Molecular Weight	653.54