LAS190792

Modify Date: 2024-09-16 08:11:57

LAS190792 Structure
LAS190792 structure
Common Name LAS190792
CAS Number 1347232-69-2 Molecular Weight 811.36
Density N/A Boiling Point N/A
Molecular Formula C39H43ClN4O9S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LAS190792


LAS190792 (AZD8999) is a potent muscarinic antagonist and β2-adrenoceptor agonist with pIC50 8.9, 8.8, 8.8, 9.2, 8.2, 7.5, 9.1, 5.6 for M1, M2, M3, M4, M5, β1, β2, β3, respectively. LAS190792 can be used as a bronchodilatorsup>[1].

 Names

Name LAS190792

 LAS190792 Biological Activity

Description LAS190792 (AZD8999) is a potent muscarinic antagonist and β2-adrenoceptor agonist with pIC50 8.9, 8.8, 8.8, 9.2, 8.2, 7.5, 9.1, 5.6 for M1, M2, M3, M4, M5, β1, β2, β3, respectively. LAS190792 can be used as a bronchodilatorsup>[1].
Related Catalog
Target

β1 adrenoceptor:7.5 (pIC50)

β2 adrenoceptor:9.1 (pIC50)

β3 adrenoceptor:5.6 (pIC50)

mAChR1:8.9 (pIC50)

mAChR2:8.8 (pIC50)

mAChR3:8.8 (pIC50)

mAChR4:9.2 (pIC50)

mAChR5:8.2 (pIC50)

References

[1]. Aparici M, et al. Pharmacological preclinical characterization of LAS190792, a novel inhaled bifunctional muscarinic receptor antagonist /β2-adrenoceptor agonist (MABA) molecule. Pulm Pharmacol Ther. 2017 Oct;46:1-10.  

 Chemical & Physical Properties

Molecular Formula C39H43ClN4O9S2
Molecular Weight 811.36
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