LAS190792

Names

[ Name ]:
LAS190792

Biological Activity

[Description]:

LAS190792 (AZD8999) is a potent muscarinic antagonist and β2-adrenoceptor agonist with pIC50 8.9, 8.8, 8.8, 9.2, 8.2, 7.5, 9.1, 5.6 for M1, M2, M3, M4, M5, β1, β2, β3, respectively. LAS190792 can be used as a bronchodilatorsup>[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> mAChR

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

β1 adrenoceptor:7.5 (pIC50)

β2 adrenoceptor:9.1 (pIC50)

β3 adrenoceptor:5.6 (pIC50)

mAChR1:8.9 (pIC50)

mAChR2:8.8 (pIC50)

mAChR3:8.8 (pIC50)

mAChR4:9.2 (pIC50)

mAChR5:8.2 (pIC50)

[References]

[1]. Aparici M, et al. Pharmacological preclinical characterization of LAS190792, a novel inhaled bifunctional muscarinic receptor antagonist /β2-adrenoceptor agonist (MABA) molecule. Pulm Pharmacol Ther. 2017 Oct;46:1-10.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₉H₄₃ClN₄O₉S₂

[ Molecular Weight ]:
811.36

Related Compounds

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