1347232-69-2

1347232-69-2 structure

Name: LAS190792
Chemical Name: LAS190792
CAS Number: 1347232-69-2
Molecular Formula: C₃₉H₄₃ClN₄O₉S₂
Molecular Weight: 811.36
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2023-01-15 05:01:11
Modify Date: 2024-09-16 08:11:57
LAS190792 (AZD8999) is a potent muscarinic antagonist and β2-adrenoceptor agonist with pIC50 8.9, 8.8, 8.8, 9.2, 8.2, 7.5, 9.1, 5.6 for M1, M2, M3, M4, M5, β1, β2, β3, respectively. LAS190792 can be used as a bronchodilatorsup>[1].

Name	LAS190792

Description	LAS190792 (AZD8999) is a potent muscarinic antagonist and β2-adrenoceptor agonist with pIC50 8.9, 8.8, 8.8, 9.2, 8.2, 7.5, 9.1, 5.6 for M1, M2, M3, M4, M5, β1, β2, β3, respectively. LAS190792 can be used as a bronchodilatorsup>[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	β1 adrenoceptor:7.5 (pIC50) β2 adrenoceptor:9.1 (pIC50) β3 adrenoceptor:5.6 (pIC50) mAChR1:8.9 (pIC50) mAChR2:8.8 (pIC50) mAChR3:8.8 (pIC50) mAChR4:9.2 (pIC50) mAChR5:8.2 (pIC50)
References	[1]. Aparici M, et al. Pharmacological preclinical characterization of LAS190792, a novel inhaled bifunctional muscarinic receptor antagonist /β2-adrenoceptor agonist (MABA) molecule. Pulm Pharmacol Ther. 2017 Oct;46:1-10.

Molecular Formula	C₃₉H₄₃ClN₄O₉S₂
Molecular Weight	811.36