Rimantadine

Modify Date: 2025-08-22 00:41:25

Rimantadine Structure
Rimantadine structure
Common Name Rimantadine
CAS Number 13392-28-4 Molecular Weight 179.30
Density 1.033 Boiling Point 248ºC
Molecular Formula C12H21N Melting Point 375°C(lit.)
MSDS N/A Flash Point 99ºC

 Use of Rimantadine


Rimantadine (Flumadine) is an anti-influenza virus drug.Target: Influenza Virusrimantadine are oral antiviral drugs useful in the prophylaxis and treatment of influenza A virus infections. rimantadine has prophylactic efficacy comparable to amantadine but lower potential for causing adverse effects [1]. double-blind study of children with influenza-like illness. 37 received rimantadine for five days. Of the total 37 children in the rimantadine group, 27% were found to have resistant isolated compared with 6% in the total group receiving acetaminophen (P < .04). Furthermore, the mean inhibitory concentration of rimantadine increased with time in the rimantadine group (r = .4, P = .002) [2].

 Names

Name 1-(1-adamantyl)ethanamine
Synonym More Synonyms

 Rimantadine Biological Activity

Description Rimantadine (Flumadine) is an anti-influenza virus drug.Target: Influenza Virusrimantadine are oral antiviral drugs useful in the prophylaxis and treatment of influenza A virus infections. rimantadine has prophylactic efficacy comparable to amantadine but lower potential for causing adverse effects [1]. double-blind study of children with influenza-like illness. 37 received rimantadine for five days. Of the total 37 children in the rimantadine group, 27% were found to have resistant isolated compared with 6% in the total group receiving acetaminophen (P < .04). Furthermore, the mean inhibitory concentration of rimantadine increased with time in the rimantadine group (r = .4, P = .002) [2].
Related Catalog
References

[1]. Tominack, R.L. and F.G. Hayden, Rimantadine hydrochloride and amantadine hydrochloride use in influenza A virus infections. Infect Dis Clin North Am, 1987. 1(2): p. 459-78.

[2]. Hall, C.B., et al., Children with influenza A infection: treatment with rimantadine. Pediatrics, 1987. 80(2): p. 275-82.

 Chemical & Physical Properties

Density 1.033
Boiling Point 248ºC
Melting Point 375°C(lit.)
Molecular Formula C12H21N
Molecular Weight 179.30
Flash Point 99ºC
PSA 26.02000
LogP 4.05230
Vapour Pressure 0.0249mmHg at 25°C
Index of Refraction 1.539
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU4716000
CHEMICAL NAME :
1-Adamantanemethylamine, alpha-methyl-
CAS REGISTRY NUMBER :
13392-28-4
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H21-N
MOLECULAR WEIGHT :
179.34

 Safety Information

Hazard Codes Xn
HS Code 2921300090

 Synthetic Route

~98%

Rimantadine Structure

Rimantadine

CAS#:13392-28-4

Literature: E. I. Du Pont de Nemours and Company Patent: US4551552 A1, 1985 ;

~85%

Rimantadine Structure

Rimantadine

CAS#:13392-28-4

Literature: Vashkevich; Kozlov; Potkin Russian Journal of Organic Chemistry, 1999 , vol. 35, # 12 p. 1773 - 1776

~%

Rimantadine Structure

Rimantadine

CAS#:13392-28-4

Literature: Journal of medicinal chemistry, , vol. 14, # 6 p. 535 - 543

 Customs

HS Code 2921300090
Summary 2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Synonyms

1-adamantanemethylamine
tricyclo[3.3.1.1]decane-1-methanamine, α-methyl-, hydrochloride
a-Methyltricyclo[3.3.1.13,7]decane-1-methanamine Hydrochloride
Remantadine
Meradan
α-Methyl-1-adamantanemethylamine hydrochloride
UNII:JEI07OOS8Y
[1-(1-Adamantyl)ethyl]amine hydrochloride
Rimant
MFCD03265511
1-tricyclo[3.3.1.1]déc-1-yléthanamine chlorhydrate
1-(Adamantan-1-yl)ethanamine hydrochloride (1:1)
Roflual
Rimantadinum
1-(tricyclo[3.3.1.1]dec-1-yl)ethanamine hydrochloride (1:1)
Tricyclo[3.3.1.1]decane-1-methanamine, α-methyl-, hydrochloride (1:1)
Flumadine
a-Methyl-1-adamantanemethylamine Hydrochloride
1-Tricyclo[3.3.1.1]dec-1-ylethanaminhydrochlorid
Rimantadina
Rimantadine
Rimantadine Hydrochloride
1-tricyclo[3.3.1.1]dec-1-ylethanamine hydrochloride
Riamantadine
Remantadine hydrochloride
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