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Rimantadine

Names

[ CAS No. ]:
13392-28-4

[ Name ]:
Rimantadine

[Synonym ]:
1-adamantanemethylamine
tricyclo[3.3.1.1]decane-1-methanamine, α-methyl-, hydrochloride
a-Methyltricyclo[3.3.1.13,7]decane-1-methanamine Hydrochloride
Remantadine
Meradan
α-Methyl-1-adamantanemethylamine hydrochloride
UNII:JEI07OOS8Y
[1-(1-Adamantyl)ethyl]amine hydrochloride
Rimant
MFCD03265511
1-tricyclo[3.3.1.1]déc-1-yléthanamine chlorhydrate
1-(Adamantan-1-yl)ethanamine hydrochloride (1:1)
Roflual
Rimantadinum
1-(tricyclo[3.3.1.1]dec-1-yl)ethanamine hydrochloride (1:1)
Tricyclo[3.3.1.1]decane-1-methanamine, α-methyl-, hydrochloride (1:1)
Flumadine
a-Methyl-1-adamantanemethylamine Hydrochloride
1-Tricyclo[3.3.1.1]dec-1-ylethanaminhydrochlorid
Rimantadina
Rimantadine
Rimantadine Hydrochloride
1-tricyclo[3.3.1.1]dec-1-ylethanamine hydrochloride
Riamantadine
Remantadine hydrochloride

Biological Activity

[Description]:

Rimantadine (Flumadine) is an anti-influenza virus drug.Target: Influenza Virusrimantadine are oral antiviral drugs useful in the prophylaxis and treatment of influenza A virus infections. rimantadine has prophylactic efficacy comparable to amantadine but lower potential for causing adverse effects [1]. double-blind study of children with influenza-like illness. 37 received rimantadine for five days. Of the total 37 children in the rimantadine group, 27% were found to have resistant isolated compared with 6% in the total group receiving acetaminophen (P < .04). Furthermore, the mean inhibitory concentration of rimantadine increased with time in the rimantadine group (r = .4, P = .002) [2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus
Research Areas >> Infection

[References]

[1]. Tominack, R.L. and F.G. Hayden, Rimantadine hydrochloride and amantadine hydrochloride use in influenza A virus infections. Infect Dis Clin North Am, 1987. 1(2): p. 459-78.

[2]. Hall, C.B., et al., Children with influenza A infection: treatment with rimantadine. Pediatrics, 1987. 80(2): p. 275-82.


[Related Small Molecules]

Baloxavir | Pimodivir | KIN1148 | Zanamivir | Arbidol HCl | Nucleozin | Theaflavin | Desaminotyrosine | Peramivir Trihydrate | RIG-1 modulator 1 | Rimantadine Hydrochloride | Sodium copper chlorophyllin | SP187 | Dehydroandrographolide | M2 ion channel blocker

Chemical & Physical Properties

[ Density]:
1.033

[ Boiling Point ]:
248ºC

[ Melting Point ]:
375°C(lit.)

[ Molecular Formula ]:
C12H21N

[ Molecular Weight ]:
179.30

[ Flash Point ]:
99ºC

[ PSA ]:
26.02000

[ LogP ]:
4.05230

[ Vapour Pressure ]:
0.0249mmHg at 25°C

[ Index of Refraction ]:
1.539

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU4716000
CHEMICAL NAME :
1-Adamantanemethylamine, alpha-methyl-
CAS REGISTRY NUMBER :
13392-28-4
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H21-N
MOLECULAR WEIGHT :
179.34

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2921300090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921300090

[ Summary ]:
2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Related Compounds

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