Nucleozin

Names

[ Name ]:
Nucleozin

[Synonym ]:
Nucleozin|
(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-methyl-3-phenylisoxazol-4-yl)methanone
[4-(2-chloro-4-nitrophenyl)piperazin-1-yl]-[3-phenyl-5-methylisoxazol-4-yl]methanone
Nucleozin

Biological Activity

[Description]:

Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication. IC50 Value: Target: Influenza Virus NPNucleozin targets influenza A nucleoprotein, a multifunctional, RNA-binding protein necessary for virus replication. It induces the formation of nucleoptotein aggregates and inhibits its accumulation, interfering with viral replication. EC50 is in the nM range. Nucleozin is effective in H1N1, H3N2, and H5N1 flu virus strains.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

[References]

[1]. Kao, Richard Y. et al. Identification of influenza A nucleoprotein as an antiviral target.Nature Biotechnology (2010), 28(6), 600-605.

[2]. Hung HC, Liu CL, Hsu JT, Horng JT, Fang MY, Wu SY, Ueng SH, Wang MY, Yaw CW, Hou MH.Development of an anti-influenza drug screening assay targeting nucleoproteins with tryptophan fluorescence quenching.Anal Chem. 2012 Aug 7;84(15):6391-9. Epub 2012 Jul 10.

[3]. Su CY, Cheng TJ, Lin MI, Wang SY, Huang WI, Lin-Chu SY, Chen YH, Wu CY, Lai MM, Cheng WC, Wu YT, Tsai MD, Cheng YS, Wong CH.High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity.Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19151-6. Epub 2010 Oct 25.

[4]. Kao RY, Yang D, Lau LS, Tsui WH, Hu L, Dai J, Chan MP, Chan CM, Wang P, Zheng BJ, Sun J, Huang JD, Madar J, Chen G, Chen H, Guan Y, Yuen KY.Identification of influenza A nucleoprotein as an antiviral target.Nat Biotechnol. 2010 Jun;28(6):600-5. Epub 2010 May 30.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.371

[ Boiling Point ]:
673.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₉ClN₄O₄

[ Molecular Weight ]:
426.85300

[ Flash Point ]:
361.3ºC

[ Exact Mass ]:
426.10900

[ PSA ]:
95.40000

[ LogP ]:
4.70010

[ Index of Refraction ]:
1.631

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Articles

A GFP-tagged nucleoprotein-based aggregation assay for anti-influenza drug discovery and antibody development.

Analyst 138(20) , 6073-80, (2013)

Influenza is a viral pandemic that affects millions of people worldwide. Seasonal variations due to genetic shuffling and antigenic drifts in the influenza viruses have necessitated continual updating...