Moroxydine (hydrochloride)

Names

[ Name ]:
Moroxydine (hydrochloride)

[Synonym ]:
Moroxydine (hydrochloride)
4-Morpholinecarboximidoylguanidine Hydrochloride
abobhydrochloride
Moroxydine hydrochlorid
Hydrogen chloride - N-carbamimidoyl-4-morpholinecarboximidamide (1:1:1)
N-Carbamimidoyl-4-morpholinecarboximidamide chlorhydrate (1:1)
assur
Moroxydine hydrochloride
4-Morpholinecarboximidamide, N-(aminoiminomethyl)-, chloride, hydrogen salt (1:1)
N-Carbamimidoyl-4-morpholincarboximidamidhydrochlorid(1:1)
N1,N1-Anhydrobis(b-hydroxyethyl)biguanide Hydrochloride
N,N-oxapentamethylenebiguanide hydrochloride
virusmin
N-Carbamimidoyl-4-morpholinecarboximidamide hydrochloride
virustat
N1-morpholinobiguanidine hydrochloride
Miejunging
N-amidino-4-morpholincarboxamidine*hydrochloride
Malinguchlorate
Abitilguanide Hydrochloride
flumidin
1-Morpholinobiguanide Hydrochloride
N-(aminoiminomethyl)-4-morpholinecarboximidamide hydrochloride (1:1)
4-Morpholinecarboximidamide, N- (aminoiminomethyl)-, monohydrochloride
morpholinebiguanide monohydrochloride
spenitol
N-carbamimidoylmorpholine-4-carboximidamide hydrochloride
MORPHOLINO-BIUANIDE HYDROCHLORIDE
MOROXYDINE HCL
Abitylguanide Hydrochloride
N-Carbamimidoylmorpholine-4-carboximidamide hydrochloride (1:1)
morpholinebiguanidine hydrochloride

Biological Activity

[Description]:

Moroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.Target: Influenza VirusMoroxydine is an antiviral drug that was originally developed in the 1950s as an influenza treatment. It has potential applications against a number of RNA and DNA viruses [1]. Structurally moroxydine is a heterocyclic biguanidine. Moroxydine was reported in March 2014 that three kindergartens in two provinces of China had been found to be secretly dosing their students with moroxydine hydrochloride to try to prevent them from becoming ill. The kindergartens are paid only for the days that pupils attend and wanted to ensure that they maximised their earnings [2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

[References]

[1]. Sheppard, S., Moroxydine: the story of a mislaid antiviral. Acta Derm Venereol Suppl (Stockh), 1994. 183: p. 1-9.

[2]. Moore, Malcolm. "China: All children to be given drug tests after schools caught medicating pupils". The Age. Retrieved 2014-03-20.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
327ºC at 760 mmHg

[ Melting Point ]:
211-214ºC(lit.)

[ Molecular Formula ]:
C₆H₁₄ClN₅O

[ Molecular Weight ]:
207.661

[ Flash Point ]:
151.6ºC

[ Exact Mass ]:
207.088684

[ PSA ]:
98.22000

[ LogP ]:
0.76700

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD9815000

CHEMICAL NAME :: 4-Morpholinecarboxamidine, N-amidino-, monohydrochloride

CAS REGISTRY NUMBER :: 3160-91-6

LAST UPDATED :: 199501

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C6-H13-N5-O.Cl-H

MOLECULAR WEIGHT :: 207.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 18,196,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 325 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-37/39

[ WGK Germany ]:
3

[ RTECS ]:
QD9815000

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%