Lipoamido-PEG8-acid

Modify Date: 2024-01-10 20:21:24

Lipoamido-PEG8-acid Structure
Lipoamido-PEG8-acid structure
Common Name Lipoamido-PEG8-acid
CAS Number 1334172-70-1 Molecular Weight 629.824
Density 1.2±0.1 g/cm3 Boiling Point 748.3±60.0 °C at 760 mmHg
Molecular Formula C27H51NO11S2 Melting Point N/A
MSDS N/A Flash Point 406.4±32.9 °C

 Use of Lipoamido-PEG8-acid


Lipoamido-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 33-(1,2-Dithiolan-3-yl)-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azatritriacontan-1-oic acid
Synonym More Synonyms

 Lipoamido-PEG8-acid Biological Activity

Description Lipoamido-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 748.3±60.0 °C at 760 mmHg
Molecular Formula C27H51NO11S2
Molecular Weight 629.824
Flash Point 406.4±32.9 °C
Exact Mass 629.290344
LogP -1.15
Vapour Pressure 0.0±5.4 mmHg at 25°C
Index of Refraction 1.507

 Synonyms

33-(1,2-Dithiolan-3-yl)-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azatritriacontan-1-oic acid
4,7,10,13,16,19,22,25-Octaoxa-28-azatritriacontan-1-oic acid, 33-(1,2-dithiolan-3-yl)-29-oxo-
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