1246189-43-4

1246189-43-4 structure

Name: Bis-PEG8-acid
Chemical Name: Bis-PEG8-acid
CAS Number: 1246189-43-4
Molecular Formula: C₂₀H₃₈O₁₂
Molecular Weight: 470.51
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2020-04-12 16:20:25
Modify Date: 2024-01-20 12:41:40
Bis-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	Bis-PEG8-acid

Description	Bis-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Gregory Slobodkin, et al. Polyamine derivatives. WO2010108108A2