JAK1-IN-31

Modify Date: 2023-03-08 22:57:58

JAK1-IN-31 structure	Common Name	JAK1-IN-31
	CAS Number	1315498-72-6	Molecular Weight	449.529
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₃N₅O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JAK1-IN-31

JAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM, less potent for JAK3 (Ki=280 nM) and Tyk2 (Ki=12 nM) and no inhibition on hERG and CYP3A4 (IC50>10 uM); exhibits favorable oral bioavailability across a range of preclinical species and robust efficacy in a rat CIA model.

Name	JAK1-IN-31

Description	JAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM, less potent for JAK3 (Ki=280 nM) and Tyk2 (Ki=12 nM) and no inhibition on hERG and CYP3A4 (IC50>10 uM); exhibits favorable oral bioavailability across a range of preclinical species and robust efficacy in a rat CIA model.
References	References 1. Zak M, et al. J Med Chem. 2013 Jun 13;56(11):4764-85. View Related Products by Target JAK

Molecular Formula	C₂₃H₂₃N₅O₃S
Molecular Weight	449.529

DC Chemicals Limited
China
Product Name: JAK1-IN-31
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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