2091134-35-7
2091134-35-7 structure
- Name: JAK1-IN-4
- Chemical Name: AZD4205
- CAS Number: 2091134-35-7
- Molecular Formula: C26H32FN9O2
- Molecular Weight: 521.6
- Catalog: Signaling Pathways Epigenetics JAK
- Create Date: 2018-01-03 11:42:16
- Modify Date: 2026-07-01 19:42:12
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JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM)[1].
| Name | AZD4205 |
|---|
| Description | JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM)[1]. |
|---|---|
| Related Catalog | |
| Target |
JAK1:85 nM (IC50) JAK2:12.8 μM (IC50) |
| References |
[1]. Annika Birgitta Margareta ÅSTRAND, et al. Compounds and methods for inhibiting jak. |
| Molecular Formula | C26H32FN9O2 |
|---|---|
| Molecular Weight | 521.6 |
| Exact Mass | 521.26629946 |