1315498-72-6
1315498-72-6 structure
- Name: JAK1-IN-31
- Chemical Name: JAK1-IN-31
- CAS Number: 1315498-72-6
- Molecular Formula: C23H23N5O3S
- Molecular Weight: 449.529
- Create Date: 2020-01-20 07:20:57
- Modify Date: 2023-03-08 22:57:58
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JAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM, less potent for JAK3 (Ki=280 nM) and Tyk2 (Ki=12 nM) and no inhibition on hERG and CYP3A4 (IC50>10 uM); exhibits favorable oral bioavailability across a range of preclinical species and robust efficacy in a rat CIA model.
| Name | JAK1-IN-31 |
|---|
| Description | JAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM, less potent for JAK3 (Ki=280 nM) and Tyk2 (Ki=12 nM) and no inhibition on hERG and CYP3A4 (IC50>10 uM); exhibits favorable oral bioavailability across a range of preclinical species and robust efficacy in a rat CIA model. |
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| References | References 1. Zak M, et al. J Med Chem. 2013 Jun 13;56(11):4764-85. View Related Products by Target JAK |
| Molecular Formula | C23H23N5O3S |
|---|---|
| Molecular Weight | 449.529 |